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How Does Cialis Work?
Cialis or tadalafil works by inhibiting the effect of PDE5, and it is distinguished pharmacologically by its extended half life which is up to a period of 17.5 hours, as compared to other drugs such as Levitra or Viagra. This consequently results in a longer duration of its action and this is also the reason as to why it is known as The Weekend Pill. Moreover, the extended half life duration is the reason why experts are interested in the everyday therapeutic uses of Cialis in bringing about relief from pulmonary arterial hypertension.
Cialis should be taken carefully and if you tend to experience any of its side effects, one of which is sudden loss of vision or even priapism, you should report the matter instantly to your physician.
Mechanism of Cialis
During sexual stimulation, erection in the penis is resulted by the increased flow of blood to the penis due to the relaxation of the arteries in the penile area. Another contributor to the increased circulation is the smooth muscle in the corpus cavernosum of the penis. The response is brought about by the effect of nitric oxide from the endothelial cells and the terminals of the nerves that stimulate cGMP synthesis in the smooth muscle cells. The cyclic GMP relaxes the smooth muscles and increases the flow of blood to your corpus cavernosum.
Inhibition of PDE5 or phosphodiesterase type 5 leads to the enhancement of erectile function by enhancing the level of cGMP. Cialis works by acting as an inhibitor of PDE5. However, since sexual stimulation is necessary for the initiation of the local discharge of the chemical nitric oxide from the penis, the PDE5 inhibition does not work without immediate sexual stimulation in the penis.
Recommended Intake of Cialis
Men are usually recommended to take a 10 mg dosage of Cialis as required before the commencement of sexual activity, although the drug should be taken only once a day. The dosage may be enhanced to 20 mg and even reduced to 5 mg, depending on its effect and the individual's tolerance level of the pill. In order to get rid of the inconvenience of programming and planning the intake of the drug around the estimated sexual action, clinical development programs have been started to study the risks and advantages of chronic usage of the drug once a day.
The European Commission has approved low dosage Cialis (of 2.5 mg or 5 mg) for being used as a single therapy for erectile dysfunction every day. Adcirca, another product of generic tadalafil, was approved in Europe and USA as a single daily therapy for the improvement of the ability to exercise in patients suffering from pulmonary arterial hypertension.
Cialis is meant for the healing of men suffering from ED or erectile dysfunction or from the signs of BPH or benign prostatic hyperplasia, or individuals suffering from both the conditions. The success rate of this drug is the reason why it is being sought after by men who have realized the benefits after taking the drug as recommended.
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